AP5

Item no.	HY-112603-1ea
Manufacturer	MedChem Express
CASRN	1623194-37-5
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Formula	C28H28FNO4
Citations	[1]Chen HY, et al. Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs. ACS Med Chem Lett. 2018 Jun 14;9(7):685-690.
Smiles	FC1=CC(C2=CC(OC)=NC=C2)=CC=C1[C@@H]3CCC(C=CC([C@H](C4CC4)[C@H](C)C(O)=O)=C5)=C5O3
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	AP5 is a potent, orlly active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 demonstrates rat and human inositol monophosphate (IP1) EC50 values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 has the potential for type II diabetes research[1].
Shipping	Room temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	461.52
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Solubility	10 mM in DMSO
Target	Free Fatty Acid Receptor
Manufacturers Target	Free Fatty Acid Receptor
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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