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Bisindolylmaleimide V

Bisindolylmaleimide V

Item no.	HY-112400-5mg
Manufacturer	MedChem Express
CASRN	113963-68-1
Amount	5 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	96.59
Formula	C21H15N3O2
Citations	[1]Lazareno S, et al. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol. 1998 Nov 6;360(2-3):281-4.<br/>[2]Marmy-Conus N, et al. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling. FEBS Lett. 2002 May 22;519(1-3):135-40.
Smiles	O=C(C(C1=CNC2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)N(C)C3=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BIM V
Available
Product Description	Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	341.36
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	Ribosomal S6 Kinase (RSK)
Manufacturers Target	Ribosomal S6 Kinase (RSK)
Manufacturers Pathway	MAPK/ERK Pathway
Manufacturers Product type	Reference compound

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