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(1R)-IDH889

(1R)-IDH889

Item no.	HY-112289B-5mg
Manufacturer	MedChem Express
CASRN	1429179-08-7
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.83
Formula	C23H25FN6O2
Citations	[1]Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8(2):151-156.
Smiles	O=C1OC[C@H](C(C)C)N1C2=NC(N[C@@H](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	(1R)-IDH889 is the isomer of IDH889 (HY-112289), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	436.48
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 200 mg/mL (ultrasonic)
Target	Isocitrate Dehydrogenase (IDH)
Manufacturers Target	Isocitrate Dehydrogenase (IDH)
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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