S-23

Item no.	HY-112257-100mg
Manufacturer	MedChem Express
CASRN	1010396-29-8
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.93
Formula	C18H13ClF4N2O3
Citations	[1]Jones A, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):385-395.<br/>[2]Thevis M, et al. Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens. Drug Test Anal. 2010;2(11-12):589-598.
Smiles	O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)COC2=CC=C(Cl)C(F)=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1010396-29-8
Similar products	1010396-29-8
Available
Product Description	S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	416.75
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Androgen Receptor
Manufacturers Target	Androgen Receptor
Manufacturers Pathway	Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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