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Pyrrophenone

Pyrrophenone

Item no.	HY-111376-10mg
Manufacturer	MedChem Express
CASRN	341973-06-6
Amount	10 mg
Quantity options	10mM/1mL 10 mg 1ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.76
Formula	C49H37F2N3O5S2
Citations	[1]K Seno, et al. Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'. Bioorg Med Chem Lett. 2001 Feb 26;11(4):587-90.<br/>[2]Stefania Mariggiò, et al. Cytosolic phospholipase A2 alpha regulates cell growth in RET/PTC-transformed thyroid cells. Cancer Res. 2007 Dec 15;67(24):11769-78.<br/>[3]C-H Lee, et al. Mechanism of glutamine inhibition of cytosolic phospholipase a2 (cPLA2 ): Evidence of physical interaction between glutamine-Induced mitogen-activated protein kinase phosphatase-1 and cPLA2. Clin Exp Immunol. 2015 Jun;180(3):571-80.
Smiles	O=C(NC[C@H]1N(C(C2=CC=CC=C2C(C3=CC=C(F)C=C3F)=O)=O)C[C@H](SC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)C1)C7=CC=C(/C=C(SC(N8)=O)/C8=O)C=C7
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Pyrrophenone is a potent and specific cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 4.2 nM[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	849.96
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Phospholipase
Manufacturers Target	Phospholipase
Isoform	Phospholipase A
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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