Heclin

Item no.	HY-110204-10mM
Manufacturer	MedChem Express
CASRN	890605-54-6
Amount	10mM/1mL
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.80
Formula	C17H17NO3
Citations	[1]Wang K, et al. Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancer [J]. Oncogene, 2023, 42(14): 1072-1087.<br>[2]Su B C, Chen J Y. Antimicrobial peptide epinecidin-1 modulates MyD88 protein levels via the proteasome degradation pathway [J]. Marine Drugs, 2017, 15(11): 362.<br>[3]Mund T, et al. Peptide and small molecule inhibitors of HECT-type ubiquitin ligases [J]. Proceedings of the National Academy of Sciences, 2014, 111(47): 16736-16741.
Smiles	CC(C(C=C1)=CC=C1NC(/C=C/C2=CC=C(CC)O2)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits Smurf2, Nedd4, WWP1 (IC50 values are 6.8, 6.3, 6.9 μM) and can be used for the research of gastric cancer[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	283.32
Clinical_Information	No Development Reported
Manufacturers Research_Area	Others
Solubility	DMSO : 100 mg/mL (ultrasonic)
Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10mM/1mL

available

Request delivery time