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(E/Z)-Teriflunomide

(E/Z)-Teriflunomide

Item no.	HY-110159-10mM
Manufacturer	MedChem Express
CASRN	108605-62-5
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mM x 1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.86
Formula	C12H9F3N2O2
Citations	[1]R I Fox, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93(3):198-208.
Smiles	C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(E/Z)-A77 1726
Available
Product Description	(E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA)[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	270.21
Clinical Information	Launched
Manufacturers Research Area	Infection; Inflammation/Immunology
Solubility	DMSO : 50 mg/mL (ultrasonic)
Target	Dihydroorotate Dehydrogenase
Manufacturers Target	Dihydroorotate Dehydrogenase
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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