TDZD-8

Item no.	HY-11012-25mg
Manufacturer	MedChem Express
CASRN	327036-89-5
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.81
Formula	C10H10N2O2S
Citations	[1]Martinez A, et al. First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem. 2002 Mar 14;45(6):1292-9.<br/>[2]Xie CL, et al. Inhibition of Glycogen Synthase Kinase-3β (GSK-3β) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats. Sci Rep. 2016 Mar 21;6:23527.<br/>[3]Sun A, et al. GSK-3β controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells. Prostate. 2016 Feb;76(2):172-83.
Smiles	O=C(N1CC2=CC=CC=C2)N(C)SC1=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GSK-3β Inhibitor I; NP 01139
Available
Product Description	TDZD-8 is an inhibitor of GSK-3β, with an IC50 of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II, PKA, and PKC, with all IC50s of >100 μM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	222.26
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL
Target	GSK-3
Manufacturers Target	GSK-3
Isoform	GSK-3β
Manufacturers Pathway	PI3K/Akt/mTOR; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-11012-25mg-safety-datasheet.pdf