T2AA

Item no.	HY-110111-100mg
Manufacturer	MedChem Express
CASRN	1380782-27-3
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.03
Formula	C15H15I2NO3
Citations	[1]Akira Inoue, et al. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem. 2014 Mar 7;289(10):7109-7120.
Smiles	IC(C=C(C[C@H](N)CO)C=C1I)=C1OC2=CC=C(O)C=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	511.09
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	DNA/RNA Synthesis
Manufacturers Target	DNA/RNA Synthesis
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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