BTZO-1

Item no.	HY-110084-25mg
Manufacturer	MedChem Express
CASRN	99420-15-2
Amount	25 mg
Quantity options	10mM/1mL 10 mg 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.69
Formula	C13H8N2OS
Citations	[1]Kimura H, et al. BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression.Chem Biol. 2010 Dec 22;17(12):1282-94.
Smiles	O=C1N=C(C2=NC=CC=C2)SC3=CC=CC=C13
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	99420-15-2
Available
Product Description	BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	240.28
Clinical Information	No Development Reported
Manufacturers Research Area	Cardiovascular Disease
Solubility	DMSO : 8.33 mg/mL (ultrasonic)
Target	Apoptosis; Macrophage migration inhibitory factor (MIF)
Manufacturers Target	Apoptosis; Macrophage migration inhibitory factor (MIF)
Manufacturers Pathway	Apoptosis; Immunology/Inflammation
Manufacturers Product type	Reference compound

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