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Eliapixant

Eliapixant

Item no.	HY-109170-10mg
Manufacturer	MedChem Express
CASRN	1948229-21-7
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.95
Formula	C22H21F3N4O3S
Citations	[1]Morice A, et, al. Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240.<br/>[2]Spinaci A, et, al. P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications. Front Pharmacol. 2021 Apr 13;12:653561.
Smiles	C[C@H](C1=CN=C(C(F)(F)F)N=C1)NC(C2=CC(O[C@@H]3CCOC3)=CC(C4=NC=C(S4)C)=C2)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	BAY 1817080
Available
Product Description	Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	478.49
Clinical Information	Phase 2
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Target	P2X Receptor
Manufacturers Target	P2X Receptor
Isoform	P2X3 Receptor
Manufacturers Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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