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Deoxynyboquinone

Deoxynyboquinone

Item no.	HY-108992-10mg
Manufacturer	MedChem Express
CASRN	96748-86-6
Amount	10 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.21
Formula	C15H12N2O4
Citations	[1]Elizabeth I Parkinson, et al. Deoxynyboquinones as NQO1-Activated Cancer Therapeutics. Acc Chem Res. 2015 Oct 20;48(10):2715-23.<br>[2]Joseph S Bair, et al. Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death. J Am Chem Soc. 2010 Apr 21;132(15):5469-78.<br>[3]Tudor G, et,al. Cytotoxicity and apoptosis of benzoquinones: redox cycling, cytochrome c release, and BAD protein expression. Biochem Pharmacol. 2003;65(7):1061-1075.<br>[4]Huang X, et al. An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis. Cancer Res. 2012 Jun 15;72(12):3038-47.
Smiles	O=C1N(C)C2=C(C(C(C(C)=CC(N3)=O)=C3C2=O)=O)C(C)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	284.27
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Apoptosis; Reactive Oxygen Species
Pathway	Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Manufacturers Product type	Reference compound

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Amount: 10 mg

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