BCH

Item no.	HY-108540-100mg
Manufacturer	MedChem Express
CASRN	20448-79-7
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10mg 50 mg 5mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C8H13NO2
Citations	[1]Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107(10):1499-1505.<br>[2]Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20(1).<br>[3]Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5(4):1281-94. eCollection 2015.
Smiles	O=C(C1(N)C(C2)CCC2C1)O
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1
Similar products	20448-79-7
Available
Product Description	BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	155.19
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : < 1 mg/mL\|H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Apoptosis
Pathway	Apoptosis

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