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SMANT (hydrochloride)

SMANT (hydrochloride)

Item no.	HY-108508-25mg
Manufacturer	MedChem Express
CASRN	1177600-74-6
Amount	25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.90
Formula	C16H24BrClN2O
Citations	[1]Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15;7(6):1040-8.
Smiles	O=C(NC1=CC=C(Br)C=C1)CCN2CC(C)CC(C)C2.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	375.73
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Pathway	Stem Cell/Wnt
Manufacturers Product type	Reference compound

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