JW67

Item no.	HY-108442-1ea
Manufacturer	MedChem Express
CASRN	442644-28-2
Amount	1ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	98.06
Citations	[1]Waaler J, et al. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 2011;71(1):197-205.
Smiles	O=C1C2(OCC3(COC4(C5=CC=CC=C5NC4=O)OC3)CO2)C6=CC=CC=C6N1
ECLASS 5.1	32169090
ECLASS 6.1	32169090
ECLASS 8.0	32169090
ECLASS 9.0	32169090
ECLASS 10.0.1	32169090
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	394.38
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturers Target	Wnt
Pathway	Stem Cell/Wnt
Manufacturers Product type	Reference compound

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