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(S)-(+)-Dimethindene (maleate)

(S)-(+)-Dimethindene (maleate)

Item no.	HY-107647-1ea
Manufacturer	MedChem Express
CASRN	136152-65-3
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.94
Citations	[1]Pfaff O, et al. The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur J Pharmacol. 1995;286(3):229-240.<br>[2]Yang Y, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169(2):243-257.e25.
Smiles	C[C@@H](C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3.OC(/C=C\C(O)=O)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48)[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	408.49
Clinical_Information	No Development Reported
Manufacturers Research_Area	Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturers Target	Histamine Receptor; mAChR
Isoform	H1 Receptor; mAChR1; mAChR2; mAChR3; mAChR4
Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Manufacturers Product type	Reference compound

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