Item no. |
HY-105285-50mg |
Manufacturer |
MedChem Express
|
CASRN |
946846-83-9 |
Amount |
50 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
25 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.54 |
Formula |
C17H16N2O4 |
Citations |
[1]Meihua She, et al. Piromelatine, a Novel Melatonin Receptor Agonist, Stabilizes Metabolic Profiles and Ameliorates Insulin Resistance in Chronic Sleep Restricted Rats. Eur J Pharmacol. 2014 Mar 15;727:60-5.<br/>[2]L Huang, et al. Blood Pressure Reducing Effects of Piromelatine and Melatonin in Spontaneously Hypertensive Rats. Eur Rev Med Pharmacol Sci. 2013 Sep;17(18):2449-56.<br/>[3]Yuan-Yuan Liu, et al. Piromelatine Exerts Antinociceptive Effect via Melatonin, Opioid, and 5HT1A Receptors and Hypnotic Effect via Melatonin Receptors in a Mouse Model of Neuropathic Pain. Psychopharmacology (Berl). 2014 Oct;231(20):3973-85. |
Smiles |
O=C(C1=CC(C=CO1)=O)NCCC2=CNC3=CC=C(OC)C=C23 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Neu-P11 |
Similar products |
946846-83-9 |
Available |
|
Product Description |
Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities[1][2][3]. |
StorageTemperature |
4°C (Powder, protect from light) |
Shipping |
Room Temperature |
Manufacturers Applications |
Neuroscience-Neuromodulation |
MolecularWeight |
312.32 |
Clinical Information |
Phase 3 |
Manufacturers Research Area |
Neurological Disease |
Solubility |
DMSO : 250 mg/mL (ultrasonic) |
Target |
5-HT Receptor; Melatonin Receptor; P2X Receptor; Sodium Channel; TRP Channel |
Manufacturers Target |
5-HT Receptor; Melatonin Receptor; P2X Receptor; Sodium Channel; TRP Channel |
Isoform |
5-HT1 Receptor; 5-HT2 Receptor; MT1; MT2; P2X3 Receptor |
Manufacturers Pathway |
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.