Comparison

Aminopurvalanol A European Partner

Item no. HY-104013-10mM
Manufacturer MedChem Express
CASRN 220792-57-4
Amount 10mM/1mL
Category
Type Inhibitor
Specific against other
Purity 98.25
Formula C19H26ClN7O
Citations [1]Bernabò N, et al. Aminopurvalanol A, a Potent, Selective, and Cell Permeable Inhibitor of Cyclins/Cdk Complexes, Causes the Reduction of in Vitro Fertilizing Ability of Boar Spermatozoa, by Negatively Affecting the Capacitation-Dependent Actin Polymerization. Front Physiol. 2017;8:1097.<br>[2]Rosania GR, et al. A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc Natl Acad Sci U S A. 1999;96(9):4797-4802.
Smiles CC(C)N1C2=NC(N[C@@H](CO)C(C)C)=NC(NC3=CC(Cl)=CC(N)=C3)=C2N=C1
ECLASS 5.1 30220300
ECLASS 6.1 30220300
ECLASS 8.0 32160605
ECLASS 9.0 32160605
ECLASS 10.0.1 32160490
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Product Description
Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization[1][2].
StorageTemperature
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping
Room Temperature
Manufacturers Applications
Cancer-Kinase/protease
MolecularWeight
403.91
Clinical_Information
No Development Reported
Manufacturers Research_Area
Cancer
Solubility
DMSO : 100 mg/mL (ultrasonic)
Manufacturers Target
Apoptosis; CDK
Pathway
Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type
Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10mM/1mL
Available: In stock
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