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Samuraciclib

Samuraciclib

Item no.	HY-103712-1ea
Manufacturer	MedChem Express
CASRN	1805833-75-3
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Formula	C22H30N6O
Citations	Int J Mol Sci. 2022 Feb 24;23(5):2493.<br/>J Cancer Res Clin Oncol. 2022 Nov 18.<br/>Cell Death Dis. 2019 Aug 9;10(8):602.<br/>Clin Cancer Res. 2024 Feb 21.<br/>Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12986-12995. <br/>Structure. 2024 Jun 9:S0969-2126(24)00188-6.<br/>[1]Hazel P, et al. Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem. 2017 Mar 7;12(5):372-380.<br/>[2]Patel H, et al. ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. Mol Cancer Ther. 2018 Jun;17(6):1156-1166.
Smiles	O[C@H]1CNCC[C@@H]1CNC2=NC3=C(C(C)C)C=NN3C(NCC4=CC=CC=C4)=C2
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	CT7001; ICEC0942
Available
Product Description	Samuraciclib (CT7001) is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 µM. Samuraciclib has anti-tumor effects[1][2].
Shipping	Room temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	394.51
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	Apoptosis; CDK
Manufacturers Target	Apoptosis; CDK
Isoform	CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Manufacturers Pathway	Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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