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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	1 ea
Item no.	HY-103544
CASRN	96736-12-8
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	[D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P activates G12. [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P stimulates an increase in neutrophil migration and Ca2+ mobilization. [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer[1][2][3]
Shipping	Room temperature
MolecularWeight	1516.83
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer; Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturers Target	Bombesin Receptor; Interleukin Related; JNK
Pathway	GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway
Manufacturers Product type	Peptides

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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