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MRS1845

MRS1845

Item no.	HY-103310-10mM
Manufacturer	MedChem Express
CASRN	544478-19-5
Amount	10mM/1mL
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.69
Formula	C21H22N2O6
Citations	[1]Harper JL, et al. Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells. Biochem Pharmacol. 2003 Feb 1;65(3):329-38.<br>[2]Abdelazeem KNM, et al. Upregulation of Orai1 and STIM1 expression as well as store-operated Ca<sup>2+</sup> entry in ovary carcinoma cells by placental growth factor. Biochem Biophys Res Commun. 2019 May 7;512(3):467-472.<br>[3]Ma K, et al. Phosphate-induced ORAI1 expression and store-operated Ca<sup>2+</sup> entry in aortic smooth muscle cells. J Mol Med (Berl). 2019 Oct;97(10):1465-1475.
Smiles	O=C(C1=C(C)N(CC#C)C(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC50 of 1.7 μM[1]. MRS1845 is an ORAI1 inhibitor[2][3]. MRS1845 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	398.41
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cardiovascular Disease
Solubility	DMSO : ≥ 125 mg/mL\|DMSO : ≥ 83.33 mg/mL\|DMSO : 125 mg/mL (ultrasonic)
Manufacturers Target	Calcium Channel; CRAC Channel
Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

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Amount: 10mM/1mL

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