PIT-1

Item no.	HY-103224-50mg
Manufacturer	MedChem Express
CASRN	53501-41-0
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.56
Formula	C14H10ClN3O4S
Citations	[1]Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.
Smiles	O=C(NC(NC1=CC([N+]([O-])=O)=CC(Cl)=C1O)=S)C2=CC=CC=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	PIT-1 is a selective PIP3 (phosphatidylinositol 3, 4, 5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo[1].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	351.76
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Target	PI3K
Manufacturers Target	PI3K
Manufacturers Pathway	PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

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