ML381

Item no.	HY-101839-1mg
Manufacturer	MedChem Express
CASRN	1623481-80-0
Amount	1 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C21H21N3O4
Citations	[1]Gentry PR, et al. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe. ChemMedChem. 2014 Aug;9(8):1677-82.
Smiles	O=C(C1=NOC(COC2=CC=CC(C(C)=O)=C2)=C1)N(C)[C@H](C3=NC=CC=C3)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VU0488130
Available
Product Description	ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC50 = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	379.41
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturers Target	mAChR
Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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