IPAG

Item no.	HY-100985-10mg
Manufacturer	MedChem Express
CASRN	193527-91-2
Amount	10 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.84
Formula	C17H22IN3
Citations	[1]James M Brimson, et al. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. Sci Rep. 2020 Jun 8;10(1):9251. [2]Halley M Oyer, et al.Small-Molecule Modulators of Sigma1 and Sigma2/TMEM97 in the Context of Cancer: Foundational Concepts and Emerging Themes. Front Pharmacol. 2019 Oct 21;10:1141. [3]Felix J Kim, et al. Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun. 2012 Sep 21;426(2):177-82.
Smiles	N=C(NC1=CC=C(I)C=C1)NC2[C@H]3C[C@H](C4)C[C@@H]2C[C@H]4C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3[1]. IPAG induces apoptosis[2].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	395.28
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 8.33 mg/mL (ultrasonic; adjust pH to 3 with 1M HCl; heat to 60°C)
Manufacturers Target	Sigma Receptor
Pathway	Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-100985-10mg-safety-datasheet.pdf