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Y-33075 (dihydrochloride)

Y-33075 (dihydrochloride)

Item no.	HY-10069-25mg
Manufacturer	MedChem Express
CASRN	173897-44-4
Amount	25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.75
Formula	C16H18Cl2N4O
Citations	Adv Sci (Weinh). 2022 Mar 3;e2104682.<br>Cell. 2018 Jul 26;174(3):636-648.e18.<br>Harvard Medical School LINCS LIBRARY<br>J Adv Res. 2023 Oct 6:S2090-1232(23)00299-0.<br>Nat Commun. 2020 Jan 3;11(1):88.<br>Neurotox Res. 2013 Apr;23(3):238-48.<br>Science. 2017 Dec 1;358(6367):eaan4368.<br>J Cell Physiol. 2021 Jun 27.<br>Patent. US20170349879A1.<br>PLoS One. 2023 Jan 31;18(1):e0270288.<br>Stem Cell Rep. 2020 Jan 14;14(1):49-59.<br>[1]Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11.<br>[2]Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70.<br>[3]Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222
Smiles	O=C(C1=CC=C([C@@H](C)N)C=C1)NC2=C3C(NC=C3)=NC=C2.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	353.25
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 50 mg/mL (ultrasonic)
Manufacturers Target	ROCK
Isoform	ROCK
Pathway	Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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