« Back
Home /
Rilmenidine (hemifumarate)

Rilmenidine (hemifumarate)

Item no.	HY-100490A-50mg
Manufacturer	MedChem Express
CASRN	207572-68-7
Amount	50 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.82
Formula	C10H16N2O.1/2C4H4O4
Citations	[1]Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S.<br/>[2]Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.<br/>[3]Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153.
Smiles	O=C(O)/C=C/C(O)=O.C1(NC(C2CC2)C3CC3)=NCCO1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells [1][2][3].
StorageTemperature	-20°C (Powder, stored under nitrogen, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	238.28
Clinical Information	Launched
Manufacturers Research Area	Cancer; Cardiovascular Disease
Solubility	DMSO : 10 mg/mL (ultrasonic)\|H2O : 50 mg/mL (ultrasonic)
Target	Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor
Manufacturers Target	Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor
Manufacturers Pathway	Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 50 mg

available

Request delivery time