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SRI-011381

SRI-011381

Item no.	HY-100347-50mg
Manufacturer	MedChem Express
CASRN	1629138-41-5
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.58
Formula	C20H31N3O
Citations	Cell Immunol. 2023 Nov 2, 104781.<br/>Dis Markers. 2022 May 7;2022:9230647.<br/>J Agric Food Chem. 2022 Aug 25.<br/>Oncol Lett. 2024 Mar 26.<br/>Phytother Res. 2022 Nov 28.<br/>Biomed Res Int. 2020 Nov 16;2020:8039840.<br/>Biosci Rep. 2020 Nov 27;40(11):BSR20201545.<br/>Cancer Cell Int. 2022 May 16;22(1):191.<br/>Cell Commun Signal. 2023 Jul 4;21(1):168.<br/>Cell Cycle. 2021 Jan 26;1-15.<br/>Cell Mol Biol Lett. 2023 Feb 27;28(1):15.<br/>Chem Res Toxicol. 2022 Feb 21;35(2):233-243.<br/>Curr Med Sci. 2019 Aug;39(4):534-540.<br/>Dev Comp Immunol. 2018 Nov;88:144-151. <br/>Drug Dev Res. 2019 Nov;80(7):992-999. <br/>Eur J Pharmacol. 2021 Oct 5;908:174356.<br/>Evid Based Complement Alternat Med. 2023 Jan 12;2023:6018375.<br/>Exp Eye Res. 2019 Mar 23;182:44-56.<br/>J Cardiothorac Surg. 2024 May 10;19(1):283.<br/>J Cell Mol Med. 2021 Apr;25(7):3272-3283.<br/>J Ethnopharmacol. 2023 Dec 18:117507.<br/>Laryngoscope. 2024 May 21.<br/>Life Sci. 2021 Aug 15;279:119359.<br/>Mol Cell Biochem. 2019 Jun;456(1-2):95-104. <br/>Mol Med Rep. 2021 Nov;24(5):758.<br/>Nature. 2023 Jan;613(7942):120-129.<br/>Neurobiol Dis. 2024 Jun 18:199:106573.<br/>Oncol Lett. 2024 May 30.<br/>Phytomedicine. 1 June 2022, 154234.<br/>Phytomedicine. 2022 Mar 21;100:154067.<br/>Reprod Domest Anim. 2022 Oct 28.<br/>Research Square Preprint. 2020 Dec.<br/>Stem Cells. 2024 May 8:sxae032.<br/>Theranostics. 2021; 11(17):8480-8499.<br/>[1]Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978.<br/>[2]Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499.
Smiles	O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	329.48
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)
Target	TGF-beta/Smad
Manufacturers Target	TGF-beta/Smad
Manufacturers Pathway	Stem Cell/Wnt; TGF-beta/Smad
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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