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PF 477736

PF 477736

Item no.	HY-10032-5mg
Manufacturer	MedChem Express
CASRN	952021-60-2
Amount	5 mg
Quantity options	10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.21
Formula	C22H25N7O2
Citations	Cancers. 2019 Oct 25;11(11):1654.<br>Harvard Medical School LINCS LIBRARY<br>Research Square Preprint. 2022 Jul.<br>Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.<br>Science. 2017 Dec 1;358(6367):eaan4368.<br>Exp Mol Med. 2021 Sep 22.<br>[1]Blasina A, et al. Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1. Mol Cancer Ther. 2008 Aug;7(8):2394-404<br>[2]Ashwell S, et, al. DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy. Clin Cancer Res. 2008 Jul 1; 14(13): 4032-7.
Smiles	O=C([C@@H](C1CCCCC1)N)NC2=CC3=C(C(C=NNC4=O)=C(N3)C5=CN(N=C5)C)C4=C2
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PF 00477736
Available
Product Description	PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	419.48
Clinical_Information	Phase 1
Manufacturers Research Area	Cancer
Solubility	DMSO : 125 mg/mL (ultrasonic)
Manufacturers Target	Aurora Kinase; CDK; c-Fms; Checkpoint Kinase (Chk); FGFR; FLT3; RET; Src; VEGFR
Isoform	Aurora A; CDK1; Chk1; Chk2; FGFR3; VEGFR2/KDR/Flk-1
Pathway	Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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