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Antihistamine-1

Antihistamine-1

Item no.	HY-100238-25mg
Manufacturer	MedChem Express
CASRN	1186430-60-3
Amount	25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.45
Formula	C23H24FN5
Citations	[1]Lavrador-Erb K, et al. The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia. Bioorg Med Chem Lett. 2010 May 1;20(9):2916-9.
Smiles	CC1=CN(C2CCN(C3=NC4=CC=CC=C4N3CC5=CC=C(F)C=C5)CC2)N=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	389.47
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease; Endocrinology
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Cytochrome P450; Histamine Receptor; Potassium Channel
Isoform	CYP2; H1 Receptor
Pathway	GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Manufacturers Product type	Reference compound

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