SPDP

Item no.	HY-100216-5mg
Manufacturer	MedChem Express
CASRN	68181-17-9
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.84
Formula	C12H12N2O4S2
Citations	[1]Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7.<br>[2]Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.
Smiles	O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SPDP Crosslinker
Available
Product Description	SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs)[1][2].
StorageTemperature	-20°C (Powder, protect from light, stored under nitrogen)
Shipping	Blue Ice
MolecularWeight	312.36
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 155 mg/mL (ultrasonic)
Manufacturers Target	ADC Linker
Isoform	Cleavable Linker; Disulfide Cleavable Linker
Pathway	Antibody-drug Conjugate/ADC Related
Manufacturers Product type	ADC Related

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