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Anisomycin (Flagecidin)

Anisomycin (Flagecidin)

Item no.	AGSC-A-1049-10mg
Manufacturer	AG Scientific
Amount	10mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	22862-76-6
Available
Description	Anisomycin is an antifungal produced by Streptomyces griseolus. It functions by inhibiting protein synthesis in certain eukaryotic cells. Anisomycin inhibits peptidyl transferase activity in the 60s subunit of the 80s ribosome. It also increases the phosphorylation of p70 S6 kinase α . Anisomycin has been shown to promote apoptosis in promyelocytic leukemia cells, Jurkat cells, ventricular monocytes, and colon adenocarcinoma cells. Additionally, anisomycin is a JNK agonist and activates MAP kinases. It is used in Martin-Lewis Medium to inhibit candida albicans and aid in identification of N. gonorrhoeae. Finally, Anisomycin or Flagecidin is also an anti-protozoal agent.
CAS #	22862-76-6
Chemical Name	2-[(4-METHOXYPHENYL)METHYL]-3, 4-PYRROLIDINEDIOL 3-ACETATE
Molecular Weight	265, 3
Melting Point	139-141° C
Boiling Point	398.7± 42.0 ° C at 760 mmHg
Purity	>98% by HPLC
Solubility	Soluble in DMSO
Appearance	White powder
Storage	-20° C
ChemACX	X1000859-4
MDL Number	MFCD00077650
Chemical Formula	C₁₄H₁₉NO₄
InChI	InChI=1S/ C14H19NO4/ c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/ h3-6, 12-15, 17H, 7-8H2, 1-2H3/ t12-, 13+, 14+/ m0/ s1
Smiles	CC(=O)O[C@H]1[C@@H](CN[C@H]1Cc2ccc(cc2)OC)O

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Amount: 10mg

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