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Epidermal Growth Factor
Epidermal growth factor (EGF) is a protein that stimulates the growth of various epidermal and epithelial tissues1. It consists of 54 amino acids (6.3 kDa), which are linked by 3 intramolecular disulfide bonds2. It occurs increasingly in the initiation of mitosis. For research purposes it can be used both in vitro and in vivo. In some fibroblasts it also stimulates the described growth in cell culture1.
Fig. 1: Amino acid sequence of the epidermal growth factor (EGF).
Epidermal growth factor receptor
EGF is one of the major ligands of the epidermal growth factor receptor family (EGFR). The receptor belongs to the class of transmembrane glycoproteins and consists of an extracellular receptor domain, a transmembrane region and an intracellular domain which functions as a tyrosine kinase3. When EGF binds to EGFR, autophosphorylation of the receptor tyrosine kinase takes place, which leads to the activation of certain signal transduction pathways. Among other pathways, cell proliferation and cell differentiation are regulated by this type of signal transduction 4.
Fig. 2: EGFR consists of an extracellular receptor domain, a transmembrane region and an intracellular domain, which acts as a tyrosine kinase.
Research areas
EGFR plays a special role in the study of cancer, as it is overexpressed in a variety of tumor cells. Overexpression of EGFR has been found particularly in solid tumors, e.g. Breast cancer, head and neck cancer, non-small cell lung cancer (NSCLC), kidney cancer, ovarian cancer and colon cancer 5. The activation of the receptor is also associated with resistance to chemotherapy and radiation. The described properties of EGFR make the receptor an important therapeutic target in the treatment of cancer, since interactions with EGFR may lead to an interruption of signal transduction 6.
Particularly inhibitors of EGFR were monoclonal antibodies directed against the extracellular receptor domain and low molecular weight compounds7. Both monoclonal antibodies and low molecular weight compounds can cause cell proliferation to be disrupted and apoptosis facilitated. Consequently, the cytotoxic as well as cytostatic properties can be attributed to the substances mentioned 7.
Fig. No. 3: The figure shows a detailed overview of the EGFR signaling pathway.
Products
Antibody
RayBiotech
|
Name |
Typ |
Specific against |
Host |
ArtNr. |
Menge |
|
Antibody |
Rabbit |
other |
127-10497 |
100ul |
|
|
Antibody |
Mouse |
Hu |
128-10066-1 |
500 ug |
|
|
Antibody |
Mouse |
Hu |
128-10066-2 |
1mg |
|
|
Antibody |
Goat |
Mu |
DS-PB-00691 |
0.1 mg |
|
|
Antibody |
Goat |
Mu |
DS-PB-00692 |
50 ug |
|
|
Antibody |
Rabbit |
Hu |
DS-PB-00693 |
0.1 mg |
|
|
Antibody |
Rabbit |
Hu |
DS-PB-00694 |
50 ug |
|
|
Antibody |
Mouse |
other |
MD-02-0003 |
100 ug |
|
|
Antibody |
Mouse |
other |
MD-02-0004 |
100 ug |
|
|
Antibody |
Mouse |
Hu |
MD-02-0005 |
100 ug |
Cloud-Clone
|
Name |
Typ |
Specific against |
Host |
ArtNr. |
Menge |
|
Antibody Monoclonal |
Hu |
Mouse |
MAA560Hu22_100ug |
100ug |
|
|
Antibody Monoclonal |
Po |
Mouse |
MAA560Po21_100ug |
100ug |
|
|
Antibody Monoclonal |
Ra |
Mouse |
MAA560Ra21_100ug |
100ug |
|
|
Antibody Monoclonal |
Hu |
Mouse |
MAA560Hu22_20ug |
20ug |
|
|
Antibody Monoclonal |
Po |
Mouse |
MAA560Po21_20ug |
20ug |
|
|
Antibody Monoclonal |
Ra |
Mouse |
MAA560Ra21_20ug |
20ug |
|
|
Antibody Monoclonal |
Po |
Mouse |
MAA560Po21_200ug |
200ug |
|
|
Antibody Monoclonal |
Ra |
Mouse |
MAA560Ra21_200ug |
200ug |
|
|
Antibody Monoclonal |
Hu |
Mouse |
MAA560Hu22_200ug |
200ug |
|
|
Monoclonal Antibody to Epidermal Growth Factor Receptor 2 (EGFR2) |
Antibody Monoclonal |
Hu |
Mouse |
MAB867Hu22_200ug |
200ug |
|
Monoclonal Antibody to Epidermal Growth Factor Receptor (EGFR) |
Antibody Monoclonal |
Hu |
Mouse |
MAA757Hu22_200ug |
200ug |
Sino Biological Inc.
|
Name |
Typ |
Specific against |
Host |
ArtNr. |
Menge |
|
Epidermal Growth Factor/EGF Antibody, Rabbit PAb, Antigen Affinity Purified |
Antibody |
other |
101619-T32-50 |
50 ug |
|
|
Epidermal Growth Factor/EGF Antibody, Rabbit PAb, Antigen Affinity Purified |
Antibody |
other |
101619-T32-100 |
100 ug |
|
|
Epidermal Growth Factor/EGF Antibody, Rabbit PAb, Antigen Affinity Purified |
Antibody |
other |
101619-T32-200 |
200 ug |
|
|
Antibody |
other |
80446-MM02-50 |
50 ug |
||
|
Antibody |
other |
80446-MM02-100 |
100 ug |
||
|
Antibody |
other |
80446-MM02-200 |
200 ug |
||
|
Antibody |
other |
10001-RE11-50 |
50 ug |
||
|
Antibody |
other |
10001-RE11-100 |
100 ug |
||
|
Antibody |
other |
10001-RE11-1 |
1 mg |
||
|
Antibody |
other |
10001-MM08-A-25 |
25 Tests |
||
|
Antibody |
other |
10001-RE01-A-25 |
25 Tests |
||
|
Antibody |
other |
10001-MM08-P-25 |
25 Tests |
||
|
Antibody |
other |
10001-RE01-P-25 |
25 Tests |
||
|
Antibody |
other |
10001-MM08-F-25 |
25 Tests |
||
|
Antibody |
other |
10001-RE01-F-25 |
25 Tests |
||
|
Antibody |
other |
10001-R021-1 |
1 mg |
ELISA-Kit
RayBiotech Inc.
|
Name |
Typ |
Host |
ArtNr. |
Menge |
|
Elisa-Kit |
E.coli |
ELH-EGF-1 |
1 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
E.coli |
ELH-EGF-2 |
2 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
E.coli |
ELH-EGF-5 |
5 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
E.coli |
ELM-EGF-1 |
1 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
E.coli |
ELM-EGF-2 |
2 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
E.coli |
ELM-EGF-5 |
5 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
|
ELK-EGF-1 |
1 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
|
ELK-EGF-2 |
2 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
|
ELK-EGF-5 |
5 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
|
ELHS-EGF-1 |
1 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
|
ELHS-EGF-2 |
2 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
|
ELHS-EGF-5 |
5 x 96-Well Strip Microplate Kit |
|
|
Elisa-Kit |
E.coli |
ELR-EGF-1 |
1 x 96-Well Strip Microplate Kit |
Sino Biological Inc.
|
Name |
Typ |
Specific against |
ArtNr. |
Menge |
|
Elisa-Kit |
Hu |
KIT10001 |
1 Kit (96 Tests) |
|
|
Elisa-Kit |
Hu |
KIT10001-1 |
96 Tests |
Cloud-Clone Corp.
|
Name |
Typ |
Specific against |
ArtNr. |
Menge |
|
Elisa-Kit |
other |
MEA560Mu |
96T |
|
|
Elisa-Kit |
Hu |
SEA560Hu |
96T |
|
|
Elisa-Kit |
Mu |
SEA560Mu |
96T |
|
|
Elisa-Kit |
Po |
SEA560Po |
96T |
|
|
Elisa-Kit |
Ra |
SEA560Ra |
96T |
|
|
Elisa-Kit |
Ra |
SEB286Ra |
96T |
|
|
Elisa-Kit |
Hu |
SEB286Hu-5 |
5x96T |
|
|
Elisa-Kit |
Mu |
SEB286Mu-5 |
5x96T |
|
|
Elisa-Kit |
Ra |
SEB286Ra-5 |
5x96T |
|
|
Elisa-Kit |
Hu |
SEB286Hu-10 |
10x96T |
|
|
Elisa-Kit |
Mu |
SEB286Mu-10 |
10x96T |
|
|
Elisa-Kit |
Ra |
SEB286Ra-10 |
10x96T |
Proteins
RayBiotech Inc.
|
Name |
Typ |
Specific against |
Host |
ArtNr. |
Menge |
|
Proteins |
other |
|
230-10053-100 |
100 ug |
|
|
Proteins |
other |
|
230-20031-200 |
200 ul |
|
|
Proteins |
Ra |
|
DS-01-0091 |
10 ug |
|
|
Proteins |
Hu |
|
213-10068-2 |
500 ug |
|
|
Proteins |
Mu |
|
213-10069-AF-1 |
100 ug |
|
|
Proteins |
Mu |
|
213-10069-AF-2 |
500 ug |
|
|
Proteins |
Mu |
|
228-10361-2 |
50 ug |
|
|
Proteins |
Ra |
|
228-10363-2 |
5 ug |
|
|
Proteins |
Ra |
|
228-10363-3 |
10 ug |
|
|
Neuregulin-1/Heregulin Alpha (EGF Domain), Human Recombinant |
Proteins |
Hu |
|
228-20231-2 |
20 ug |
|
Neuregulin-1/Heregulin Alpha (EGF Domain), Human Recombinant |
Proteins |
Hu |
|
228-20231-3 |
1 mg |
|
Proheparin-Binding EGF-like Growth Factor, Rat Recombinant |
Proteins |
Ra |
|
228-20114-2 |
50 ug |
|
Proheparin-Binding EGF-like Growth Factor, Rat Recombinant |
Proteins |
Ra |
|
228-20114-3 |
1 mg |
|
Proteins |
Ra |
|
229-20329 |
100 ug |
|
|
Proteins |
Hu |
|
229-20136 |
500 ug |
|
|
Proteins |
Hu |
|
268-10048-1 |
100 ug |
|
|
Proteins |
Hu |
|
268-10048-2 |
500 ug |
|
|
Proteins |
Hu |
|
268-10048-3 |
1 mg |
|
|
Proteins |
Hu |
|
268-10048-4 |
5 mg |
|
|
Proteins |
Mu |
|
268-10049-1 |
100 ug |
|
|
Proteins |
Mu |
|
268-10049-2 |
500 ug |
|
|
Proteins |
Mu |
|
268-10049-3 |
1 mg |
|
|
Proteins |
Mu |
|
268-10049-4 |
5 mg |
|
|
Proteins |
Ra |
|
268-10050-1 |
20 ug |
|
|
Proteins |
Ra |
|
268-10050-2 |
100 ug |
Sino Biological Inc.
|
Name |
Typ |
Specific against |
Host |
ArtNr. |
Menge |
|
Proteins |
Hu |
E.coli |
10605-HNAE-1 |
1 mg |
|
|
Proteins |
Hu |
E.coli |
10605-HNAE-500 |
500 ug |
|
|
Proteins |
Hu |
E.coli |
10605-HNAE-100 |
100 ug |
|
|
Proteins |
Mu |
Human |
50482-MNCH-1 |
1 mg |
|
|
Proteins |
Mu |
Human |
50482-MNCH-500 |
500 ug |
|
|
Proteins |
Mu |
Human |
50482-MNCH-100 |
100 ug |
|
|
Proteins |
Hu |
Human |
10605-H01H-1 |
1 mg |
|
|
Proteins |
Hu |
Human |
10605-H01H-500 |
500 ug |
|
|
Proteins |
Hu |
Human |
10605-H01H-100 |
100 ug |
|
|
Proteins |
Hu |
Human |
11609-H01H-100 |
100 ug |
|
|
Proteins |
Hu |
Human |
11609-H01H-50 |
50 ug |
|
|
Proteins |
Hu |
Human |
11609-H01H-5 |
5 ug |
|
|
Proteins |
Hu |
Human |
13499-H01H-50 |
50 ug |
|
|
Proteins |
Hu |
Human |
13499-H01H-100 |
100 ug |
|
|
Proteins |
Ca |
Human |
70084-D04H-5 |
5 ug |
|
|
Proteins |
Ca |
Human |
70084-D04H-100 |
100 ug |
|
|
Proteins |
Ca |
Human |
70084-D04H-50 |
50 ug |
|
|
Proteins |
Ca |
Human |
70084-D04H-10 |
10 ug |
References
|
1 |
Nair P. (2005) Epidermal growth factor receptor family and its role in cancer progression. Curr. Sci. 88, 890-898.
|
|
2 |
Carpenter G, Cohen S (May 1990). "Epidermal growth factor". The Journal of Biological Chemistry. 265(14): 7709–12. PMID 2186024
|
|
3 |
Carpenter G, Cohen S. Epidermal growth factor. Annu Rev Biochem 1979; 48:193–216.
|
|
4 |
Franklin WA, Veve R, Hirsch FR, et al. Epidermal growth factor receptor family in lung cancer and premalignancy. Semin Oncol 2002; 29 (Suppl 4):3–14.
|
|
5 |
Herbst RS, Langer CJ. Epidermal growth factor receptors as a target for cancer treatment: The emerging role of IMC-C225 in the treatment of lung and head and neck cancer. Semin Oncol 2002;29:27–36.
|
|
6 |
Iliakis G. Cell cycle regulation in irradiated and nonirradiated cells. Semin Oncol 1997; 24:602–615.
|
|
7 |
Wakeling AE, Barker AJ, Daview DH, et al. Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines. Breast Cancer Res Treat 1996;38:67– 73
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