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Loureirin B

Loureirin B

Item no.	HY-N1504-10mg
Manufacturer	MedChem Express
CASRN	119425-90-0
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 5 mg
Specific against	other
Purity	99.16
Citations	[1]Sha Y, et al. Loureirin B promotes insulin secretion through inhibition of KATP channel and influx of intracellular calcium. J Cell Biochem. 2017 Aug 17. [2]He T, et al. Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway. Cell Physiol Biochem. 2015;37(2):666-76. [3]Bai X, et al. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Exp Dermatol. 2015 May;24(5):355-60. [4]Yu Jiang, et al. Bioactivity-Guided Fractionation of the Traditional Chinese Medicine Resina Draconis Reveals Loureirin B as a PAI-1 Inhibitor. Evidence-Based Complementary and Alternative Medicine
Smiles	O=C(C1=CC=C(O)C=C1)CCC2=C(OC)C=C(OC)C=C2OC
Available
Product Description	Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	316.35
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Solubility	DMSO : ≥ 150 mg/mL
Target	ERK; JNK; PAI-1; Potassium Channel
Manufacturers Target	ERK; JNK; PAI-1; Potassium Channel
Isoform	ERK; JNK
Manufacturers Pathway	MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Stem Cell/Wnt
Manufacturers Product type	Natural Products

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HY-N1504-10mg-safety-datasheet.pdf