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L-Ascorbic acid (sodium salt)

L-Ascorbic acid (sodium salt)

Item no.	HY-B0166A-5g
Manufacturer	MedChem Express
Amount	5 g
Quantity options	10g 10 mM/1 mL 1 g 500 mg 5 g
Specific against	other
Purity	99.97
Citations	[1]Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [2]Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50. [3]Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7. [4]Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53. [5]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [6]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.
Smiles	O[C@@H](CO)[C@]1([H])C(O[Na])=C(O)C(O1)=O
Available
Product Description	L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Applications	Cancer-programmed cell death
Molecular Weight	198.11
Clinical Information	Launched
Manufacturer - Research Area	Cancer
Solubility	DMSO : 1 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Target	Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species
Isoform	Microbial Metabolite; T-type calcium channel
Pathway	Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Manufacturer - Category	Natural Products

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HY-B0166A-5g-safety-datasheet.pdf