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Serpin B9-IN-1

Serpin B9-IN-1

Item no.	HY-33299-5g
Manufacturer	MedChem Express
CASRN	154235-77-5
Amount	5 g
Quantity options	10 mM/1 mL 1 g 5 g
Category	Reagents & Chemicals Other Chemicals
Type	Chemical Reagents
Specific against	other
Purity	98.0
Citations	[1]Huang Y, et al. Mass Spectrometry-Based Proteomics Identifies Serpin B9 as a Key Protein in Promoting Bone Metastases in Lung Cancer. Mol Cancer Res. 2024 Apr 2;22(4):402-414.
Smiles	O=C(C1=CC=C2N=COC2=C1)O
ECLASS 10.1	42020190
ECLASS 11.0	42020190
UNSPSC	12000000
Alias	BTCA
Shipping condition	Room temperature
Available
Manufacturer - Type	Biochemical Assay Reagents
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Biochemical Assay Reagents
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Product Description	Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM)[1].
Manufacturer - Research Area	cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Others
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-33299-5g-safety-datasheet.pdf