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Quizartinib

Quizartinib

Item no.	HY-13001-1mg
Manufacturer	MedChem Express
Amount	1 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 200 mg 500 mg 50 mg 5 mg
Specific against	other
Purity	99.01
Citations	[1]Zarrinkar PP, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood, 2009, 114(14), 2984-2992. [2]Puissant A, et al. SYK is a critical regulator of FLT3 in acute myeloid leukemia. Cancer Cell. 2014 Feb 10;25(2):226-42. [3]Sun X, et al. PROTACs: great opportunities for academia and industry. Signal Transduct Target Ther. 2019 Dec 24;4:64.
Smiles	O=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C=C2)C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3
Available
Product Description	Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Applications	Cancer-Kinase/protease
Molecular Weight	560.67
Clinical Information	Launched
Manufacturer - Research Area	Cancer
Solubility	DMF : 10 mg/mL (ultrasonic)\|DMSO : ≥ 33 mg/mL
Target	Apoptosis; FLT3; Ligands for Target Protein for PROTAC
Pathway	Apoptosis; PROTAC; Protein Tyrosine Kinase/RTK
Manufacturer - Category	Reference compound

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HY-13001-1mg-safety-datasheet.pdf