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Oleic Acid-2,6-diisopropylanilide

Oleic Acid-2,6-diisopropylanilide

Item no.	HY-120984
Manufacturer	MedChem Express
CASRN	140112-65-8
Amount	1 ea
Specific against	other
Citations	[1]Roth, et al. Inhibitors of acyl-CoA: Cholesterol acyltransferase. 1. Identification and structure-activity relationship of a novel series of fatty acid anilide hypocholesterolemic agents. J. Med. Chem. 35(9), 1609-1617 (1992).
Smiles	CC(C1=C(C(C(C)C)=CC=C1)N(C(CCCCCCC/C=C\CCCCCCCC)=O)[H])C
Available
Product Description	AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.1 Oleic acid-2, 6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC50 of 7 nM.2 When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2, 6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.
Shipping	Room temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	441.73
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Target	Endogenous Metabolite
Manufacturers Target	Endogenous Metabolite
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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