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BIX-01294

BIX-01294

Item no.	HY-10587-25mg
Manufacturer	MedChem Express
Amount	25 mg
Quantity options	10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Specific against	other
Purity	98.75
Citations	[1]Kubicek S, et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007 Feb 9;25(3):473-81. [2]Yang Q, et al. BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells. Cell Prolif. 2012 Aug;45(4):335-44. [3]Nathaniel W Mabe, et al. G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program. Cell Rep. 2020 Nov 3;33(5):108341. [4]Iwona Anna Ciechomska, et al. BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells. Sci Rep [5]Yanqi Chang, et al.Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol. 2009 Mar;16(3):312-7.
Smiles	COC1=C(OC)C=C(C(NC2CCN(CC3=CC=CC=C3)CC2)=NC(N4CCN(C)CCC4)=N5)C5=C1
Available
Product Description	BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1, 4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells[1][2][3][4][5].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Applications	Cancer-programmed cell death
Molecular Weight	490.64
Clinical Information	No Development Reported
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 110 mg/mL\|H2O : < 0.1 mg/mL (ultrasonic)
Target	Autophagy; Histone Methyltransferase
Isoform	EHMT1/GLP/KMT1D; EHMT2/G9a/KMT1C
Pathway	Autophagy; Epigenetics
Manufacturer - Category	Reference compound

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HY-10587-25mg-safety-datasheet.pdf