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HEAT (hydrochloride)

HEAT (hydrochloride)

Item no.	HY-100980-10mg
Manufacturer	MedChem Express
CASRN	30007-39-7
Amount	10 mg
Quantity options	100 mg 10 mg 1 ea
Category	Inhibitors & Compound Libraries Compound Libraries
Specific against	other
Citations	[1]Chiu G, et al. Design and synthesis of an alpha1a-adrenergic receptor subtype-selective antagonist from BE2254. Chem Biol Drug Des. 2006;67(6):437-439. [2]McPherson GA, et al. A study of alpha 1-adrenoceptors in rat renal cortex: comparison of [3H]-prazosin binding with the alpha 1-adrenoceptor modulating gluconeogenesis under physiological conditions. Br J Pharmacol. 1982;77(1):177-184. [3]Tsujimoto G, et al. Alpha adrenergic receptors in the rabbit bladder base smooth muscle: alpha-1 adrenergic receptors mediate contractile responses. J Pharmacol Exp Ther. 1986;236(2):384-389.
Smiles	O=C1C(CNCCC2=CC=C(O)C=C2)CCC3=C1C=CC=C3.Cl
Alias	BE2254 (hydrochloride)
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Adrenergic Receptor
Shipping Temperature	Room Temperature
Product Description	HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively[1][2].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Clinical information	Phase 4

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