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Elastatinal

Elastatinal

Item no.	HY-100397-5mg
Manufacturer	MedChem Express
CASRN	51798-45-9
Amount	5 mg
Quantity options	100 mg 1 ea 5 mg
Category	Inhibitors & Compound Libraries Compound Libraries
Specific against	other
Purity	85.00
Citations	[1]Umezawa H. Structures and activities of protease inhibitors of microbial origin. Methods Enzymol. 1976;45:678-95. [2]Feinstein G, et, al. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim Biophys Acta. 1976 May 13;429(3):925-32. [3]Sugisaki R, et, al. Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin. Bone. 2020 Mar;132:115216. [4]Vidhya R, et, al. Anti-inflammatory effects of troxerutin are mediated through elastase inhibition. Immunopharmacol Immunotoxicol. 2020 Oct;42(5):423-435.
Smiles	O=C[C@H](C)NC([C@H](CCC(N)=O)NC([C@H]([C@@]1([H])NC(N)=NCC1)NC(N[C@H](C(O)=O)CC(C)C)=O)=O)=O
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Elastase
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Product Description	Elastatinal is a potent and competitive inhibitor of elastase, with a Ki of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease[1][2][3][4].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMF : 33 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported

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