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Varenicline-d4

Varenicline-d4

Item no.	HY-10019S-500ug
Manufacturer	MedChem Express
CASRN	2183239-01-0
Amount	500 ug
Quantity options	1 mg 500 ug 5 mg
Category	Inhibitors & Compound Libraries Compound Libraries
Specific against	other
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]Bagdas D, et al. New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice.Neuropharmacology. 2018 Aug;138:72-79. [3]Mihalak KB, et al. Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.Mol Pharmacol. 2006 Sep;70(3):801-5. Epub 2006 Jun 9.
Smiles	[2H]C1([2H])NC([2H])([2H])C2CC1C3=CC4=NC=CN=C4C=C32
Alias	CP 526555-d4
Shipping condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Isotope-Labeled Compounds; nAChR
Shipping Temperature	Room Temperature
Product Description	Varenicline-d4 is deuterium labeled Varenicline. Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively[1]. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment[2].
Manufacturer - Research Area	Neurological Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Clinical information	No Development Reported

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