Item no. |
HY-100116A-100mg |
Manufacturer |
MedChem Express
|
CASRN |
845959-50-4 |
Amount |
100 mg |
Quantity options |
100 mg
10 mM/1 mL
10 mg
1 mg
25 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.09 |
Citations |
Acta Pharm Sin B. 21 July 2021. Acta Pharmacol Sin. 2021 Jul 22. Adv Sci (Weinh). 2024 Sep 20:e2404753. Aging Cell. 2021 Aug 30;e13468. Am J Cancer Res. 2021 Mar 1;11(3):691-711. Antimicrob Agents Chemother. 2023 May 4;e0009823. Antioxidants (Basel). 2022 Apr 19;11(5):799. Antioxidants (Basel). 2024 Aug 19;13(8):1004. Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. Biomaterials. 2022 Dec 30;294:121986. Biomaterials. 2022, 121986. bioRxiv. 2024 August 06. bioRxiv. 2024 Mar 23. Brain. 2021 Nov 29;144(10):3126-3141. Cancer Lett. 2021 Aug 1;512:1-14. Cell Death Dis. 2021 Sep 8;12(9):839. Cell Death Dis. 2022 Jun 6;13(6):531. Cell Metab. 2020 Dec 17;S1550-4131(20)30656-2. Cell Metab. 2023 Jan 3;35(1):200-211.e9. Cell Rep. 2020 Nov 3;33(5):108340. Chemosphere. 2023 Feb 24;138249. Commun Biol. 2022 Jul 22;5(1):726. Curr Biol. 2020 Sep 7;30(17):3378-3396.e7. Ecotoxicol Environ Saf. 2022 Jan 29;232:113219. Ecotoxicol Environ Saf. 2022 Jun 15;238:113595. Ecotoxicol Environ Saf. 2023 Oct 1, 264, 115409. EMBO J. 2023 Jul 6;e113258. EMBO Rep. 2021 Apr 6;e51532. EMBO Rep. 2023 Jun 26;e56635. EMBO Rep. 2024 Mar 13. Environ Health Perspect. 2024 Jun;132(6):67009. Environ Int. 2024 May 22:188:108771. Eur J Pharm Sci. 2022 Dec 7;106350. Eur J Pharmacol. 2024 Dec 15. Exp Cell Res. 2021 Nov 18;112934. Exp Gerontol. 2024 Mar 16:189:112401. Exp Mol Med. 2023 Mar 3. Fachbereich Biologie. 2020 Oct. Free Radic Biol Med. 2021 Feb 17;S0891-5849(21)00093-9. Free Radic Biol Med. 2024 Feb 2:214:54-68. Free Radic Biol Med. 2024 Jul 9:S0891-5849(24)00552-5. Free Radic Biol Med. 2024 Mar:214:28-41. Immunology. 2024 Jun 27. Int Immunopharmacol. 2021 Jan;90:107149. Int Immunopharmacol. 2023 Dec 7:127:111328. Int J Mol Sci. 2023 May 24, 24(11), 9176. J Agric Food Chem. 2021 Jun 30. J Cell Mol Med. 2024 May;28(9):e18353. J Dairy Sci. 2023 Sep 18;S0022-0302(23)00686-0. J Equine Vet Sci. 2024 Aug 14:105168. J Exp Med. 2021 Sep 6;218(9):e20202637. J Inflamm Res. 3 August 2022. J Mol Cell Biol. 2022 Dec 23;mjac073. J Mol Neurosci. 2024 Mar 13. J Tradit Chinese Medical Sci. 2023 Feb 10. Lat Am J Pharm. 2023 Feb 16; 42(1). Mediat Inflamm. 2020 Aug 17;2020:3934769. Microchemical Journal. 2024 Nov 28. Mol Ther. 2021 Jun 7;S1525-0016(21)00313-0. Nat Cell Biol. 2024 Jul 12. Nat Commun. 2022 Aug 6;13(1):4583. Nat Commun. 2023 Jul 24;14(1):4456. Neurotoxicology. 2023 Jan 27;S0161-813X(23)00018-9. Oncogene. 2021 Nov 12. Oxid Med Cell Longev. 01 Jun 2022. Oxid Med Cell Longev. 14 Aug 2021. Oxid Med Cell Longev. 2021 Aug 31;2021:5608133. Oxid Med Cell Longev. 2022 Sep 20;2022:2213503. Patent. US20230088747A1. Phytother Res. 2024 Aug 1. PLoS One. 2021 Jan 12;16(1):e0245155. Redox Biol. 2020 Sep;36:101604. Redox Biol. 2021 Aug 18;46:102113. Redox Biol. 2021 Jul;43:101977. Redox Biol. 2021, 101936. Redox Biol. 2022 Feb;49:102216. Redox Biol. 2022 Jun 15;54:102367. Research Square Preprint. 2021 Jul. Research Square Preprint. 2023 Jul 24. Research Square Preprint. 2023 Sep 1. Sci Rep. 2024 Oct 14;14(1):24044. Sci Rep. 2024 Sep 10;14(1):21154. Sci Total Environ. 2021 Nov 24;151899. SSRN. 16 Feb 2022. SSRN. 2023 May 22. SSRN. 2024 Jan 9. Toxicol Appl Pharmacol. 2023 Mar 7;116452. Toxicol In Vitro. 2022 Jul 13;105436. Toxicol In Vitro. 2022 Oct 19;105487. Toxicol Res (Camb). 08 September 2022. Toxicology. 2023 Feb 24;487:153466. Toxicology. 2024 Apr 21:504:153812. Acta Pharmacol Sin. 2024 Jan 10. Antioxidants (Basel). 2024 Jan 17;13(1):115. Biomed Pharmacother. 2020 Jun;126:110040. Biomed Pharmacother. 2023 Apr 12;162:114680. Chem Eng J. 2020 May. Free Radic Biol Med. 2024 Jan 17:213:79-89. Front Microbiol. 2023 Oct 31. J Exp Clin Cancer Res. 2020 Jun 23;39(1):119. J Neurosci Res. 2019 Dec;97(12):1689-1705. J Transl Med. 2022 May 14;20(1):222. Oxid Med Cell Longev. 2019 Dec 3;2019:5820415. Oxid Med Cell Longev. 2020 Mar 3;2020:2167129. PLoS Pathog. 2023 May 8;19(5):e1011381. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19635-19645. Toxicol Appl Pharmacol. 2019 May 1;370:78-92. [1]Mitchell T, et al. The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renaltubular cells and rat kidneys. J Pharmacol Exp Ther. 2011 Mar;336(3):682-92. [2]Huang W, et al. Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis. Mediators Inflamm. 2015;2015:901780. |
Smiles |
[O-]S(=O)(C)=O.O=C(C(CCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=C4C)C(OC)=C(OC)C4=O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
MitoQ (mesylate), MitoQ10 (mesylate) |
Shipping condition |
Cool pack |
Available |
|
Manufacturer - Type |
Reference compound |
Manufacturer - Applications |
Cancer-programmed cell death |
Manufacturer - Targets |
Reactive Oxygen Species |
Shipping Temperature |
Blue Ice |
Storage Conditions |
-20°C (Powder, sealed storage, away from moisture) |
Molecular Weight |
678.81 |
Product Description |
Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage[1]. |
Manufacturer - Research Area |
Metabolic Disease; Cancer |
Solubility |
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |
Manufacturer - Pathway |
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB |
Clinical information |
Phase 4 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.