Golgi Matrix Protein (GM130)

GWB-137DE2

A synthetic peptide corresponding to residues in human Golgi Matrix Protein (GM130) was used as a immunogen.

WB: 1:500 - 1000FC: 1:40. Golgi Matrix Protein (GM130) is peripheral cytoplamic protein that is bound to the Golgi membranes. It has been implicated as a maintainer of cis-Golgi structure (1). During mitosis it regulates the disassembly and reassembly of the Golgi complex. It is also linked to docking and fusion of coatomer (COP I) coated vesicles to the Golgi membrane (2). The COOH-terminal domain of GM130 is highly homologous to Golgi human auto-antigen golgin-95. GM130 interacts specifically and GTP-dependent manner with Rab1b protein a regulator of anterograde traffic between ER and Golgi membranes (3). GM130 is also activator of YSK1 an essential player in cell migration. 1. Nakamura N et al. J Cell Biol 131:1715-1726 19952. Warren G Annual Rev Biochem 62:323-348 19933. Weide T et al. EMBO Rep 2:336-341 20014. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487