NFKBIB (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor. beta)

GWB-FA9A82

1:62500

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation explaining its slower degradation.

Cytoplasm (By similarity). Nucleus (By similarity).

Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.

Contains 6 ANK repeats. Summary: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910) RELA (MIM 164014) or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA MIM 164008 or NFKBIB) which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA MIM 600664 or IKBKB MIM 603258) marks them for destruction via the ubiquitination pathway thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A C or T; R is an A or G purine; and Y is a C or T pyrimidine). [supplied by OMIM]. Lee. Y. . et al. . (2003) Mol. Hum. Reprod. 9 (4). 213-218.