MCM2 (pSer41) BLOCKING PEPTIDE

MCM2 (pSer41)

Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division. Ref. 1Subunit structureInteracts with DBF4 By similarity. Interacts with MYST2. May interact with MCM10. Ref. 8Ref. 13Subcellular locationNucleusRef. 1. Post-translational modificationPhosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. Ref. 9Ref. 10Ref. 11Ref. 12Ref. 14Ref. 15Ref. 16Ref. 17Ref. 18Ref. 19Ref. 20Ref. 21Ref. 22Ref. 23Ref. 25Ref. 26Ref. 27Sequence similaritiesBelongs to the MCM family. Contains 1 MCM domain. Sequence cautionThe sequence BAA04642. 1 differs from that shown. Reason: Erroneous initiation. The sequence BAA12177. 1 differs from that shown. Reason: Erroneous initiation. The sequence CAA47749. 1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAA47749. 1 differs from that shown. Reason: Frameshift at positions 115 124 127 129 154 158 773 and 811. 1. Gerke V. and Moss S. E. (2002) Annexins: From structure to function. Physiol. Rev. 82: 331-371. [1] \" Primary structure of human placental anticoagulant protein. \" Funakoshi T. Hendrickson L. E. McMullen B. A. Fujikawa K. Biochemistry 26:8087-8092(1987) [PubMed: 2964863] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" Structure and expression of cDNA for an inhibitor of blood coagulation isolated from human placenta: a new lipocortin-like protein. \" Iwasaki A. Suda M. Nakao H. Nagoya T. Saino Y. Arai K. Mizoguchi T. Sato F. Yoshizaki H. Hirata M. Miyata T. Shidara Y. Murata M. Maki M. J. Biochem. 102:1261-1273(1987) [PubMed: 2963810] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] PROTEIN SEQUENCE OF 2-320. [3] \" Cloning and expression of cDNA for human vascular anticoagulant a Ca2+-dependent phospholipid-binding protein. \" Maurer-Fogy I. Reutelingsperger C. P. M. Pieters J. Bodo G. Stratowa C. Hauptmann R. Eur. J. Biochem. 174:585-592(1988) [PubMed: 2455636] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] PARTIAL PROTEIN SEQUENCE. [4] \" Cloning and expression of cDNA for human endonexin II a Ca2+ and phospholipid binding protein. \" Kaplan R. Jaye M. Burgess W. H. Schlaepfer D. D. Haigler H. T. J. Biol. Chem. 263:8037-8043(1988) [PubMed: 2967291] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] \" Five distinct calcium and phospholipid binding proteins share homology with lipocortin I. \" Pepinsky R. B. Tizard R. Mattaliano R. J. Sinclair L. K. Miller G. T. Browning J. L. Chow E. P. Burne C. Huang K. -S. Pratt D. Wachter L. Hession C. Frey A. Z. Wallner B. P. J. Biol. Chem. 263:10799-10811(1988) [PubMed: 2968983] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [6] \" Characterization of cDNA encoding human placental anticoagulant protein (PP4): homology with the lipocortin family. \" Grundmann U. Abel K. -J. Bohn H. Loebermann H. Lottspeich F. Kuepper H. Proc. Natl. Acad. Sci. U. S. A. 85:3708-3712(1988) [PubMed: 2967495] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [7] \" The gene encoding human annexin V has a TATA-less promoter with a high G+C content. \" Fernandez M. -P. Morgan R. O. Fernandez M. R. Carcedo M. -T. Gene 149:253-260(1994) [PubMed: 7958998] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Lung. [8] \" Organization of the human annexin V (ANX5) gene. \" Cookson B. T. Engelhardt S. Smith C. Bamford H. A. Prochazka M. Tait J. F. Genomics 20:463-467(1994) [PubMed: 8034319] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [9] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Neuroblastoma. [10] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Halleck A. Ebert L. Mkoundinya M. Schick M. Eisenstein S. Neubert P. Kstrang K. Schatten R. Shen B. Henze S. Mar W. Korn B. Zuo D. Hu Y. LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].