Insulin Growth Factor Binding Protein-2 Mouse ELISA Kit

GWB-20ACA2

Growth FactorsSample Type: SerumSensitivity: 0 04 ng/MlDescription: Enzyme Immunoassay for Quantitative Determination of Mouse-Insulin-like Growth Factor Binding Protein-2. # of Samples: 1X96 Assays
Intended Use: This IGFBP-2 Enzyme Immunoassay-Kit is suited for quantitative determination of IGFBP-2 in mouse serum for scientific purposes. Several rat sera (3 different ones) were used in this assay but no IGFBP-2 could be proved. Introduction: Insulin-like growth factors (IGFs) regulate the proliferation differentation apoptose cell adhesion and metabolism in various tissues and cell types. The IGF-I which is produced mainly in liver under the influence of Growth Hormone (GH) regulates as hormone the linear growth of the bones and the process of sexual maturity while IGF-II is mainly a growth factor of foetal tissue (11-13). The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6) (14). IGFBP-2 is after IGFBP-3 the second most frequent IGFBP in the human blood. IGFs especially tumor typical pro-IGF-forms and hormones regulate the expression of IGFBP-2 GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism (15 16). Technical Features +

Insulin Growth Factor Binding Protein-2 Mouse

Binds IGF2 more than IGF1.

Contains 1 IGFBP N-terminal domain.