Cavbeta1 S7-18

~80 55 kDa. No cross reactivity against Cav& beta; 4

1mg/mL; WB: 1-10ug/mL (if results are off try using the lysate without boiling); IHC/ICC: 0. 1-1. 0ug/mL (Perox) 1. 0-10ug/mL (IF). 1 ug/ml was sufficient for detection of Cav& beta; 1 in 10ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Storage and stability: -20& deg; C; 1 year+ Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge others conduct based on a ionic species such as sodium or potassium. Furthermore in some ion channels the passage is governed by a gate which is controlled by chemical or electrical signals temperature or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels ligand-gated other gating systems and finally those that are classified differently having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium calcium potassium proton transient receptor and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers inwardrectifier potassium channels calcium-activated potassium channels two-pore-domain potassium channels light-gated channels mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally the other classifications are based on less normal characteristics such as two-pore channels and transient receptor potential channels. Calcium channel voltage-dependent beta 1 subunit also known as CACNB1 is a human gene. The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition increasing peak calcium current controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified).