CD134


Item no.	20-783-74945
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Flow Cytometry Western Blot Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Applications	WB, FC
Clone	7D6
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-B3EA66
Similar products	20-783-74945
Available
Genway ID:	GWB-B3EA66
Specificity:	CD134
Isotype:	IgG1
Clone:	7D6
Immunogen:	CHO-derived feline CD134-Fc fusion protein.
Fusion Partner:	Spleen cells from immunised Balb/c mice were fused with cells of the NSO mouse myeloma cell line.
Specificity Note:	This product recognises feline CD134 otherwise known as OX40 a 43kDa type I membrane protein and member of the tumor necrosis factor receptor superfamily expressed predominantly by CD4+ activated T cells and a key regulator of T cell-dependent immune responses. CD134 has been identified as the receptor for the OX40 ligand CD252 expressed by activated B cells acting as a co-stimulatory signal for the stimulation and secretion of immunoglobulins. CD134 has also been identified as a binding receptor for Feline Immunodeficiency Virus (FIV) acting along with CXC chemokine receptor 4 (CXCR4) to facilitate the entry of the virus into CD4+ primary target cells.
Preparation:	Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium Azide (NaN3) Suggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Western Blot: This product detects a band of approximately 43kDa. Suggested
Dilution:	Western Blotting - 1. 0ug/ml
Function:	Receptor for TNFSF4/OX40L/GP34.
Subunit:	Interacts with TRAF2 TRAF3 and TRAF5.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Similarity:	Contains 4 TNFR-Cys repeats. 1. Arch. R. H. and Thompson. C. B. (1998) 4-1BB and OX40 are members of a tumor necrosis factor (TNF)- nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappa B. 2. Stuber. E. and Strober. W. (1996) The T cell-B cell interaction via OX40-OX40L is necessary for the T-cell dependent humoral immune response. 3. de Parseval. A. et al. (2004) Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.1 mg

available

Delivery expected until 8/30/2024