EMR3

GWB-7B379D

EMR3

ARHO-EMR3-CD97 (EGF1) transfectants.

This product recognises human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 (EMR3) which is a 56kD member of the EGF-7 transmembrane (TM7) family of adhesion receptors. EMR3 is expressed at the cell surface as a heterodimer. The molecule is predominantly expressed on granulocytes and at lower levels on mature myeloid cells monocytes and dendritic cells. EMR3 is absent on lymphocytes haematopoietic stem cells and myeloid progenitors. Studies suggest that the EMR3 molecule is up-regulated during late stages of neutrophil differentiation and is a marker for terminally differentiated cells. The exact functions of EMR3 and its ligands have not yet been determined.

Phosphate buffered saline pH7. 4

Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested

Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils.

Cell membrane; Multi-pass membrane protein.

Displays a predominantly leukocyte-restricted expression with highest levels in neutrophils monocytes and macrophages.

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily [view classification].

Contains 1 GPS domain. 1. Stacey. M. et al. (2001) Human epidermal growth factor (EGF) module-containg mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognises a ligand on human macrophages and activated neutrophils. 2. Matmati. M. et al. (2007) The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.