CD18


Item no.	20-783-72576
Manufacturer	GENWAY
Amount	2 ml
Category	Oncology Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Applications	FC, IP, IHC
Clone	L13/64
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-E54885
Similar products	20-783-72576
Available
Genway ID:	GWB-E54885
Specificity:	CD18
Specificity:	CD18
Clone:	L13/64
Immunogen:	RL-5 T cell line glycoproteins
Fusion Partner:	Spleen cells from immunised mice were fused with cells of the P3 X63. Ag8-U1 mouse myeloma cell line.
Specificity Note:	Immunoprecipitates four protein bands from RL-5 cells and spleen cells of 158 145 95 and 90kDa. These are CD11a CD11c CD18 and an intracellular precursor of CD18. Two bands are obtained from neutrophils of 155 and 95kDa. L13/64 inhibits phorbol ester-stimulated aggregation of RL-5 cells.
Preparation:	Tissue Culture Supernatant containing 0. 2M Tris/HCl pH7. 4 and 5-10% foetal calf serum
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label whole rabbit blood. Suggested
Dilution:	Flow Cytometry - Neat
Function:	Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
Subunit:	Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L alpha-M alpha-X or alpha-D. Interacts with COPS5 and RANBP9 (By similarity).
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Similarity:	Belongs to the integrin beta chain family.
Similarity:	Contains 1 VWFA domain. 1. Jackson. S. et al. (1983) Differentiation antigens identify subpopulations of rabbit T and B lymphocytes. Definition by flow cytometry 2. Wilkinson. J. M. et al. (1984) Cell surface glycoproteins of rabbit lymphocytes: characterization with monoclonal antibodies 3. Galea-Lauri. J. et al. (1993) The expression of CD11/CD18 molecules on rabbit leucocytes: identification of monoclonal antibodies to CD18 and their effect on cellular adhesion processes. 4. Channon. K. et al. (1998) Acute host-mediated endothelial injury after adenoviral gene transfer in normal rabbit arteries: impact on transgene expression and endothelial function.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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